GLIMEHELP M1
Original price was: ₹127.00.₹102.00Current price is: ₹102.00.
Mechanism: Stimulates pancreatic β-cells → ↑ insulin secretion
Indication: Type 2 Diabetes Mellitus (when diet, exercise, and/or metformin are insufficient)
Dose: 1 mg once daily, adjust per response (max usually 8 mg/day)
Description
1. Drug Profile:
Brand Name: GLIMEHELP M1
Formulation: 1 mg tablet
Class: Second-generation sulfonylurea
Pharmacokinetics: Rapid absorption; peak plasma ~2–3 hrs; metabolized in liver; excreted in urine and bile.
2. Mechanism of Action:
Glimepiride binds to sulfonylurea receptors on pancreatic β-cells, causing:
Closure of ATP-sensitive K⁺ channels
Membrane depolarization → Ca²⁺ influx
Insulin granule exocytosis → ↑ insulin secretion
Also may improve peripheral insulin sensitivity slightly.
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